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Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management - Pergolizzi - 2020 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Approximately 10-15% of patients demonstrate enhanced sensitivity, achieving therapeutic effects at doses below 5 mg daily, while 5-10% appear to be poor responders requiring doses above 10 mg daily for optimal results [4]

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10.1080/10550490490436055 Summary Keywords methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide, heroin, nervous system damage Citation Wang J, Hao Y, Ma D, Feng L, Yang F, An P, Su X and Feng J (2025) Neurotoxicity mechanisms and clinical implications of six common recreational drugs

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