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The induction of GST genes or elevated GST activities has often been observed in plants treated with beneficial bacteria (Hassan et al., Pseudomonas fluorescens to the phyllosphere of an apple scab-susceptible apple ( Malus domestica ) cultivar led to the up-regulation of genes encoding proteins participating in pathogen recognition, signaling and antimicrobial defense such as PR-proteins, thioredoxin-like proteins, heat shock proteins and a GST (Kürkcüoglu et al., 2007)

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This paradigm shift necessitates a transition from cytotoxins to a diverse array of non-cytotoxic payloads with mechanisms specifically tailored to microbial physiology, as summarized in Table 2