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The combination of low intracellular GSH levels and low expression of ABCC1 and ABCC2 in proliferative endothelial cells accounts for GSAO selectivity and subsequently for GSAO anti-angiogenic properties (Dilda et al., 2005a,b

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These observations strongly suggest that, although not required for growth in controlled environment conditions, GR1 plays a specific role in stress, particularly biotic stress