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A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight.²¹ A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg.¹⁸ Below 1 mg, estimates rely on pharmacokinetics and mechanism

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[It] also aids in DNA synthesis and is involved in the metabolism of carbohydrates, fats, and proteins." Because it's so important, those with this type of vitamin deficiency, which is diagnosed via a blood test, are usually recommended to take either supplements or get regular B12 shots