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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)

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While rare, homocystinuria is characterized by elevated homocysteine and methionine levels, which can cause whole-body complications related to vascular health, bone mineral density, neurological health, development, and eyesight