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By midlife, NAD+ can drop by 50%, exacerbated by inflammation and lifestyle.[14] Factors like poor diet, sedentary behavior, or chronic stress further deplete NAD+ by activating consuming enzymes, creating a vicious cycle

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DSIP, or delta sleep-inducing peptide, is a small neuropeptide that has been studied for possible effects on sleep regulation, stress response, and neuroendocrine signaling