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Insulin, certain GLP-1 medications, and tesamorelin for HIV-associated lipodystrophy are examples of peptide-based or peptide-like medicines with FDA-approved uses

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The multitude of targets can be specific given the activation of the VEGFR2-Akt-eNOS signaling pathway without the need for other known ligands or shear stress and evidenced controlling vasomotor tone by the activation of the Src-Caveolin-1-eNOS pathway [121,122]