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Methods: Symptomatic patients with acute stroke and persisting ICA- or M1-occlusion after intravenous lysis or mechanical thrombectomy undergo advanced neuroimaging in a time window of 72 hours after stroke onset including perfusion-MRI, blood oxygenation level dependent functional-MRI to evaluate cerebrovascular reactivity (BOLD-CVR) and non-invasive optimal vessel analysis (NOVA) quantitative-MRA to assess collateral circulation