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The ASRGL1 gene is located on chromosome 11q12.3 and is composed of 10 exons that generate two alternatively spliced mRNAs that express the same 308 amino acid protein

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Before manifesting classic symptoms like pernicious anemia, patients may experience a stage of inadequacy characterized by abnormal levels of biomarkers related to vitamin B12 deficiency, such as holotranscobalamin, methylmalonic acid, and homocysteine