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This is a well-documented fact: Vitamin B12 deficiency has a great impact on your skin, and you may experience many problems that will transform its look and feel

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Although there are some secondary biomarkers such as the measurement of certain enzyme activities in the leukocytes or the excretion of 3-hydroxy-3-methylbutyric acid in the urine, these are ambiguous indications and only a few doctors are familiar with the corresponding tests (8, 9)