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Edaravone, a free-radical scavenger approved in Japan for acute ischemic stroke, has demonstrated protective effects in tourniquet-induced muscle I/R in murine models but is not approved for limb I/R indications outside Japan

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BPC-157 upregulates VEGF (vascular endothelial growth factor) in tendon tissue, which drives the formation of new capillaries that deliver oxygen and nutrients to a repair site that was effectively starved of vascular support