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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction
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Some species of flavinogenic yeasts overproduce riboflavin in iron-sufficient media containing n-alkanes as the sole carbon source, but mechanisms of these stimulatory effects remain unknown ( The riboflavin yield is also markedly dependent on the type and initial concentrations of carbon and nitrogen sources, as well as supplementation of primary or intermediate precursors for biosynthesis