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IGF-1 LR3 is a modified analog of human Insulin-Like Growth Factor-1, engineered with two structural changes an arginine substitution and a 13-amino acid N-terminal extension that reduce its binding to IGF-1 binding proteins

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References Gasmi A, Nasreen A, Lenchyk L, Lysiuk R, Peana M, Shapovalova N, Piscopo S, Komisarenko M, Shanaida M, Smetanina K, Antonyak H, Fira L, Lykhatskyi P, Fira D, Bjørklund G