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On the other hand, uremic toxins produced by gut bacteria during protein fermentation promote systemic inflammation and kidney injury ( As CKD progresses, the impaired filtering kidneys reduce the clearance of uremic toxins, creating a toxic cycle of the aforementioned metabolic imbalances, exacerbating renal and systemic damage ( The role of SCFAs slowing the progression of CKD is increasingly being elucidated, encompassing the suppression of inflammatory responses, inhibition of oxidative stress, modulation of autophagy, enhancement of energy metabolism, and regulation of immune pathways ( Figure 2 )
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Drug Test Anal 14, 1877-1890 (2022)
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