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Angle difficulty: The awkward angle required for self-injection in the upper arm increases the risk of injecting too shallow (intradermal, which causes a painful wheal) or too deep (intramuscular)
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The mitogen-activated protein kinases (MAPKs) family, including extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun NH2-terminal kinase (JNK1/2), has been shown to play a significant role in the mediation of signals triggered by cytokines, growth factors, and environmental stress and is involved in various cellular functions [9, 10]
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