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Older adults using sermorelin for age-related GH decline should: Use 31-gauge needles to minimize tissue trauma Apply gentle pressure for 15 to 20 seconds after withdrawal (longer than the standard 10 seconds) Rotate more aggressively since older skin recovers more slowly from repeated punctures Avoid the upper arm unless assisted, as older skin in this area is often too thin Prefer the abdomen where subcutaneous fat is typically preserved even in age-related body composition changes Sermorelin was originally studied for age-related GH decline and showed sustained efficacy over 24 months in older adults (Vittone et al., 1997)

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Annals of the New York Academy of Sciences, 1033 , 30–41