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In the initial stage after overdose, APAP is rapidly metabolized to toxic NAPQI, which forms a large number of protein adducts with cellular proteins, leading to mitochondrial and cellular dysfunction followed by hepatocyte necrosis
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Caroline Ferry Caroline Ferry is a freelance journalist and copywriter, who has written for Grazia Magazine, Harper's Bazaar, Tatler and Elle and consults for many skincare, fragrance and fashion brands
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