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Several review articles [11,81,82] discuss the causal relationship between an impairment of the homeostasis of redox-active metal ion and the irreversible transformation of biological constituents, such as proteins, lipids and the DNA strand, into oxidation products, and of the following biochemical impairment to the onset of a wide array of diseases
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Rodent studies track locomotor rhythms, core temperature and hormone secretion after peptide administration at different circadian phases